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QUILLIVANT XR® FREQUENTLY ASKED QUESTIONS

Find answers to common questions about Quillivant XR® (methylphenidate hydrochloride)

What is Quillivant XR?

Quillivant XR® (methylphenidate HCl) is the first once-daily, extended-release liquid methylphenidate used for the treatment of ADHD. Quillivant XR is a central nervous system stimulant prescription liquid medicine that is taken by mouth once in the morning, with or without food. Quillivant XR may help increase attention and decrease impulsiveness and hyperactivity in people with ADHD. It is not known if Quillivant XR is safe and effective in children under 6 years of age.

Quillivant XR should be used as part of a total treatment program for ADHD that may include counseling or other therapies.

What does the XR stand for in Quillivant XR?

The “XR” stands for “eXtended Release.”

Why is Quillivant XR considered an extended-release medicine?

Quillivant XR® (methylphenidate HCl) is a long-lasting liquid methylphenidate that uses technology to allow for a continuous release of medication throughout the day. This means that Quillivant XR only needs to be taken once each day in the morning, and the medicine is released into the body throughout the day.

In a clinical study performed in a laboratory classroom, Quillivant XR was given once daily in the morning for 4 to 6 weeks, where the right dose was identified for each patient, and after remaining for 1 week on that dose. At the end of the 1-week period each child's attention and behavior were measured. Quillivant XR was found effective at reducing the symptoms of ADHD in children ages 6-12 years at all measured times (45 minutes; 2, 4, 8, 10, and 12 hours after taking) compared to a sugar syrup.

How were the effects of Quillivant XR measured?

The effectiveness of Quillivant XR® (methylphenidate HCl) was assessed in a laboratory classroom study. At the end of each week, teachers and raters used a rating scale (SKAMP) to evaluate the efficacy of Quillivant XR on attention and behavior in children with ADHD ages 6-12 years. Quillivant XR was demonstrated to start working in 45 minutes and keep working for 12 hours after taking. In a clinical study performed in a laboratory classroom, Quillivant XR was found effective at reducing the symptoms of ADHD in children ages 6-12 years at all measured times (45 minutes; 2, 4, 8, 10, and 12 hours after taking) compared to a sugar syrup.

In the clinical study, side effects of Quillivant XR were measured as reported by the parent/caregiver or the child. The most common side effects reported were mood swings, compulsive skin scratching, lack of sleep, involuntary rapid movement or speech, decreased appetite, vomiting, motion sickness, eye pain, and rash.

What does Quillivant XR taste like?

Quillivant XR® (methylphenidate HCl) is banana-flavored.

How do I store Quillivant XR?

Store Quillivant XR® (methylphenidate HCl) in a safe place at 59°F to 86°F (15°C to 30°C). Keep Quillivant XR and all medicines out of the reach of children.

How is Quillivant XR supplied?

Quillivant XR® (methylphenidate HCl) comes as a powder that your pharmacist will mix for you into a liquid. Depending on the prescription from your doctor, you will be given 1 or 2 bottles (containing the liquid form of Quillivant XR), with the bottle adapter already fully inserted by the pharmacist. You will also be given 1 oral dosing dispenser. Please refer to the Instructions for Use for a full description of each item.

How should Quillivant XR be taken?

  • Take Quillivant XR® (methylphenidate HCl) exactly as prescribed. Your healthcare provider may adjust the dose until it is right for you or your child
  • Take Quillivant XR once each day in the morning
  • Quillivant XR should be used with the oral dosing dispenser provided with the product. If the oral dosing dispenser is missing or not provided, please contact your pharmacist for a replacement
  • Quillivant XR can be taken with or without food. Taking Quillivant XR with food may shorten the time it takes for the medicine to start working
  • From time to time, your healthcare provider may stop Quillivant XR treatment for a while to check ADHD symptoms
  • Your healthcare provider may do regular checks of the blood, heart, and blood pressure while taking Quillivant XR
  • Children should have their height and weight checked often while taking Quillivant XR. Quillivant XR treatment may be stopped if a problem is found during these check-ups
  • In case of poisoning, call your poison control center at 1-800-222-1222 right away, or go to the nearest hospital emergency room

How often should Quillivant XR be taken?

Take Quillivant XR® (methylphenidate HCl) exactly as prescribed by your doctor and as instructed by your pharmacist. Quillivant XR is taken once each day in the morning.

When does Quillivant XR start working?

Quillivant XR® (methylphenidate HCl) was demonstrated to start working 45 minutes after taking. In a clinical study performed in a laboratory classroom, Quillivant XR was found effective at reducing the symptoms of ADHD in children ages 6-12 years at all measured times (45 minutes; 2, 4, 8, 10, and 12 hours after taking) compared to a sugar syrup.

How long do the effects of Quillivant XR last?

Quillivant XR® (methylphenidate HCl) works in 45 minutes and keeps working for 12 hours after taking. That means that when taken at 7 am, Quillivant XR may be effective through evening. In a clinical study performed in a laboratory classroom, Quillivant XR was found effective at reducing the symptoms of ADHD in children ages 6-12 years at all measured times (45 minutes; 2, 4, 8, 10, and 12 hours after taking) compared to a sugar syrup.

Can Quillivant XR be habit-forming?

Quillivant XR® (methylphenidate HCl) is a federally controlled substance (CII) because it can be abused or lead to dependence. Keep Quillivant XR in a safe place to prevent misuse and abuse. Selling or giving away Quillivant XR may harm others, and is against the law. Tell your healthcare provider if you or your child have (or have a family history of) ever abused or been dependent on alcohol, prescription medicines, or street drugs.

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Important Safety Information & Approved Use

DYANAVEL XR, Quillivant XR, and QuilliChew ER are federally controlled substances (CII) because they can be abused or lead to dependence. Keep these medicines in a safe place to prevent misuse and abuse. Selling or giving away these medicines may harm others and is against the law. Tell your doctor if you, your child, or any family members have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

See Additional Important Safety Information.